CBD Tolerance: Do CBD Users Build Up a Tolerance Over Time?

CBD Tolerance: Do CBD Users Build Up a Tolerance Over Time?

“Oh no.  You didn’t give little Timmy soda again, did you?” Your parents may have cringed at the thought of you having soda as a kid—or tried to keep you away from it altogether. Most likely, because just a sip would send you bouncing off the walls. This was because your body wasn’t used to the amount of caffeine you were taking in and it made you, well, a little crazy. 

As an adult, who now has at least two cups of coffee during the day to get you though, you probably don’t have the same issue. This is because over time your body has become tolerant to the caffeine. It doesn’t take a sip of soda to give you an energy buzz anymore, and your two cups of coffee probably don’t do the trick either—a few energy drinks may still give you that boost though.

Our bodies can become tolerant of many different things. But, can you build a tolerance to CBD? That is the topic we are going to explore now.

What is tolerance?

Before we talk about, “can you build a tolerance to CBD” let’s talk about what exactly tolerance is and how it happens.

Let’s say Timmy is older now and it’s not soda in his cup anymore but an alcoholic drink. However, Timmy notices that one or two drinks do not have the same effect on him as they used to—he needs more. 

Just as you can become tolerant to caffeine your body can become tolerant to many different things like alcohol. Your body is used to the substance, so you aren’t getting the same effects you used to, leaving you feeling like you need more. This can also happen with illicit and prescription drugs which can lead to dangerous results.

Your brain and your liver are the ones to blame when it comes to building a tolerance to something. Tolerance happens because the receptors in your brain that are involved decrease as does their ability to bind efficiently. Your liver also has to work harder to metabolize these substances each time you consume them.

The endocannabinoid system

To understand, “can you build a tolerance to CBD” you need to understand a little bit about cannabidiol and the endocannabinoid system. The receptors that are affected when your body becomes tolerant to something are apart of the endocannabinoid system.

The endocannabinoid system consists of receptors located all over the body and brain. The endocannabinoid system serves a vital purpose for our overall well-being. It regulates the body and essentially keeps everything “in check.”

Cannabinoid receptors are on the surface of your cells. They transmit information and kick-start the appropriate response. Cannabinoids like CBD seem to affect the cannabinoid receptors called CB1 and CB2—giving you the incredible benefits CBD has to offer. 

But, when you overuse a substance like medication or alcohol, some of these receptors will not work efficiently causing you to become tolerant of the substance. What’s interesting is that CBD may not have this same effect.

CBD tolerance vs. THC tolerance

When so many people report easily building a tolerance to marijuana, you can see why the question “can you build a tolerance to CBD” comes up frequently. 

First off, it needs to be pointed out that hemp and marijuana are very different. CBD from hemp products will not give you mind-altering effects whereas CBD from marijuana products will. This is because CBD products from hemp contain less than .3% THC while CBD products sourced from marijuana contain high amounts of THC. THC is what gives you mind-altering effects, not CBD. 

People who become tolerant of marijuana are not actually tolerant of CBD. They are tolerant of THC. After frequent use, people do seem to become tolerant of THC leaving them wanting to up their dosage. However, the research being done points to CBD not having the same effects as THC in this area either. Research seems to show that becoming tolerant of CBD is very unlikely.

Reverse tolerance

It is exciting for people who desire the medicinal properties of CBD to know when asking, “can you build a tolerance to CBD” that how people react to THC and CBD are polar opposites. CBD has actually been known to have a reverse tolerance effect.

 This means that because of its reverse tolerance effects, CBD may cause you to feel like you need smaller and smaller doses over time while still receiving the same benefits. 

Natural chemical compounds found in hemp like CBD work closely with the endocannabinoid system by attaching themselves to the receptors. Over time, the compound THC will diminish the effectiveness of these receptors. However, CBD promotes activity in these receptors.

CBD vs. Pharmaceuticals 

More and more people are searching for natural products that benefit them without uncertain and potentially dangerous side effects—unlike pharmaceuticals. 

CBD has been known to have incredible benefits for people struggling with an array of ailments such as:





Chronic Pain



Typical pharmaceuticals come with a long list of possible and sometimes dangerous side-effects. However, CBD does not seem to have any severe side-effects. Pharmaceuticals also have a bad reputation for causing people to become addicted to them. CBD does not appear to be addictive. 

Unfortunately, people can become tolerant of many different types of medications making them feel like they need more to get the same effectiveness. This can lead to an overdose which can be fatal. As mentioned, you are unlikely to become tolerant of CBD products like CBD oil or CBD edibles. There are also no known cases of fatal CBD overdose. It is important to consult your physician before replacing any medication with CBD.

Everyone is different

 It is essential to keep in mind that everyone is unique. If you feel like you could become tolerant to CBD, there are a few things that could help. In this rare case, it is recommended to take breaks when using CBD, try a different routine, a different product, or try a different dosage. 

CBD is beneficial, natural, effective, and seems to come with a much smaller risk than traditional pharmaceuticals. It may be the answer you’ve been looking for.


Due to FDA Regulations, we recommend that you do your own research on CBD products. We also suggest that you read the reviews on our website; where our customers record their real-world results of using our products.